Is there any way in ZERODHA to set stop loss and target order for stocks hold in demat and futures hold in overnight position?

Ashish, you can use after market orders option, and place your SL and target orders for overnight positions the previous evening or anytime before market opening.

Check this post:

Desperately needed. Please let us know whether this can be made possible in any way?

I tried to do this for SYNGENE in AMO with a stop loss but the order was squared off the same day. whats the problem?